Simparica Trio® Chewables for dogs

Simparica Trio is the #1 vet-prescribed combo preventative.¹ Once monthly liver-flavored chew provides dogs all-in-one protection against heartworm disease, ticks, fleas, flea tapeworms, roundworms, and hookworms. It’s approved for puppies as young as eight weeks old and weighing at least 2.8 pounds. Simparica Trio kills fleas before they can lay eggs. In studies, it starts killing fleas within 4 hours with 100% effectiveness in 8 hours. It was the first combination preventative FDA-approved to kill six types of ticks including the deer tick that may carry Lyme infections. It can be given with or without food and is loved by dogs with a study showing 9 out of 10 dogs voluntarily consumed.² Over 15 million dogs have been protected by Simparica Trio.³ Ask your vet if Simparica Trio is right for your dog or puppy. Simparica Trio comes with a 100% satisfaction guarantee on protection. If you feel that Simparica Trio isn’t providing sufficient protection, please call Zoetis’ medical support team to discuss the satisfaction guarantee at 1-888-ZOETIS1. Enrolling in auto ship provides savings, convenience, and the peace of mind that your dog never misses a dose. Simparica Trio is eligible for Zoetis Petcare Rewards Program. Sign up for free to earn points on every dollar spent on eligible purchases that can be redeemed for services at your vet. Learn more by visiting ZoetisPetcare.com/Rewards.

Use with caution in dogs with a history of seizures. Simparica Trio contains sarolaner, a member of the isoxazoline class which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea. See full Prescribing Information at SimparicaTrioPI.com.

^† As a direct result of killing deer ticks.

1. Data on file. Kynetec PetTrak US FTH National, 2025.

2. Study A161C-US-15-634. Data on file. Zoetis Inc.

3. Simparica Trio - 15M Dogs and Counting, PetTrak Kynetec Veterinary Channel Review Q4, 2024.

Dogs (8 weeks of age and older)

Sarolaner, Moxidectin, Pyrantel pamoate

Combination preventative, Chewable tablet

Simparica Trio chewable tablets are liver flavored.*

Body Weight	Sarolaner (per tablet)	Moxidectin (per tablet)	Pyrantel (per tablet)
2.8 to 5.5 lbs	3 mg	0.06 mg	12.5 mg
5.6 to 11 lbs	6 mg	0.12 mg	25 mg
11.1 to 22 lbs	12 mg	0.24 mg	50 mg
22.1 to 44 lbs	24 mg	0.48 mg	100 mg
44.1 to 88 lbs	48 mg	0.96 mg	200 mg
88.1 to 132 lbs	72 mg	1.44 mg	300 mg
>132 lbs	Administer the appropriate combination of tablets to cover the dog’s full body weight.

Please ensure the selected product and quantity are appropriate for your pet, as recommended by your veterinarian. For current availability, please refer to the product selection above.

Simparica Trio should be administered as directed by your veterinarian. Please consult your veterinarian before making any changes or discontinuing the prescribed dosing schedule.

If a dose is missed, give Simparica Trio immediately to resume monthly dosing and notify your veterinarian. Do not give two doses at once.

If multiple doses have been missed, consult your veterinarian prior to restarting the monthly dosing schedule. If you have questions about your pet’s prescribed dosing schedule (e.g., timing, interval), please contact your veterinarian.

Simparica Trio is given once a month, with or without food, as directed by your veterinarian.

Store in a cool, dry place at a controlled room temperature (at or below 86°F). Keep this and all other medications in a secure location out of the reach of children and animals. Tablets should remain sealed in their original packaging and should only be taken out of the blister pack at the time of dosing.

Exposure to extreme temperatures, light, or moisture can affect the integrity and effectiveness of medications. Always store this medication properly (e.g., away from the bathroom, kitchen sink, or other damp places).

The most common side effects of this medication are vomiting and diarrhea.

Contact your veterinarian immediately if you notice your pet has a seizure, tremors, extreme weakness, or decreased coordination (e.g., stumbling, difficulty walking).

The information provided above may not encompass all possible side effects. Please notify your veterinarian if your pet experiences any side effects, including those listed above, or if you notice anything unusual.

For oral use in dogs only.

Not for use in humans. Keep this and all medications out of reach of children and animals to prevent accidental ingestion or overdose.

Use with caution in dogs with a history of seizures or neurologic disorders.

Prior to administration of Simparica Trio, dogs should be tested for existing heartworm infections. Infected dogs should be treated with an adulticide to remove adult heartworms. Simparica Trio is not effective against adult D. immitis.

Do not administer this medication to animals with a known or suspected allergy/hypersensitivity to it or any of its ingredients. Allergic reactions to medications may occur. Please inform Vetsource and your veterinarian if your pet has any known sensitivities or allergies, especially to medications and supplements.

If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways; difficulty breathing; agitation; profuse salivation; and widespread hives or itching.

While there are no documented drug or food interactions reported for Simparica Trio, potential interactions may still be possible. As with all medications, please consult your veterinarian if you have any questions or concerns prior to use. Contact your veterinarian if your pet experiences any unusual reactions when multiple medications and/or supplements are given together.

Please ensure your veterinarian is aware of all medications, supplements, and over-the-counter (OTC) products that your pet is currently using. Your veterinarian may prescribe multiple medications, even if a potential drug interaction may occur. In these instances, your veterinarian may adjust the dosages or monitor your pet more closely.

If you are concerned that your pet has experienced an adverse reaction to this medication, please contact Zoetis at 1-888-963-8471 or Vetsource Pet Owner Care at 877-738-4443.

If you have any reason to suspect accidental consumption or overdose, call your doctor/veterinarian or the appropriate poison control resource immediately.

The national toll-free Poison Help line, 1-800-222-1222, will connect you to your local poison center in case of emergency. This service is available nationwide and in most U.S. territories.

The ASPCA Animal Poison Control Center is available 24 hours a day, 365 days a year at 888-426-4435.

Pet Poison Helpline also provides a 24/7 animal poison control service at 855-764-7661.

All content, including the images and product description above, is intended for general informational purposes only and should not be considered a substitute for professional veterinary consultation, diagnosis, or treatment.

For additional information about this product and how it fits into your pet's individual treatment plan, please consult your veterinarian.