Zoetis Inc

Revolution® Plus Feline Topical Solution

Zoetis Inc

$27.99 - $341.98

Strength & Size

2.8-5.5 lbs

5.6-11 lbs

11.1-22 lbs

Packaging

1-ct RemindMe

3 Doses

6 Doses

12 Doses

Frequency Never forget to order with AutoShip 1st order:

Quantity

Prescription required

Description

Revolution Plus (selamectin and sarolaner topical solution) for Cats

7-in-One Protection: Revolution Plus is a monthly topical that protects your cat against fleas, ticks, ear mites, roundworms, hookworms, and heartworm disease. Prevents tapeworms by killing fleas. Approved for cats and kittens eight weeks and older, weighing 2.8 lbs or more. It’s available with a prescription from your veterinarian.
Vets #1 Choice for Cats¹: Revolution Plus is the most prescribed medicine for feline parasite protection with over 25 years of proven protection*.
Protection Indoor & Outdoor Cats Need: Parasites are not “outdoor-only.” Any cat or kitten can regularly come in contact with harmful pests. Regardless of your cat’s lifestyle (indoor only, indoor/outdoor, outdoor only), Revolution Plus protects your cat from parasites that follow you home.
Once a Month Treatment: One application a month protects your cat from the most common parasites.
Easy-to-Apply: Applying Revolution Plus doesn’t require gloves. It's quick-drying, small-volume and applied topically on the back of your cat’s neck.

Revolution Plus is a simple-to-apply, quick-drying, small-volume, monthly topical solution that protects your cat against most common feline parasites: fleas, ticks, ear mites, roundworms, hookworms, and heartworm disease. It prevents flea tapeworms (Dipylidium caninum) by killing fleas. It eliminates the need for multiple treatments, simplifying your cat's parasite control routine. Whether your cat lives an indoor, outdoor or hybrid lifestyle, they are vulnerable to parasites and would benefit from Revolution Plus. When you choose Revolution Plus, you’re choosing veterinarians’ #1 choice for cats¹ with 25 years of proven protection.* Revolution Plus kills 4 types of ticks for a full month after one dose, including lone star ticks, black-legged ticks (a.k.a. deer ticks), American dog ticks and Gulf Coast ticks.² Revolution Plus kills fleas before they lay eggs and keeps killing for a full five weeks.² It started to kill fleas within 6 hours of re-infestations,² killed over 99% of ear mites for a full month, and reduced nearly 100% of roundworm and hookworms eggs after a single dose.³ Revolution Plus is available by veterinarian prescription only. Ask your vet if Revolution Plus is right for your cat or kitten. Enrolling in auto ship provides savings, convenience, and the peace of mind that your cat never misses a dose. Revolution Plus is eligible for Zoetis Petcare Rewards Program. Sign up for free to earn points on every dollar spent on eligible purchases that can be redeemed for services at your vet. Learn more by visiting ZoetisPetcare.com/Rewards.

IMPORTANT SAFETY INFORMATION:

The safe use of Revolution Plus has not been established in kittens less than 8 weeks old or in breeding, pregnant or lactating cats. Reported side effects in clinical trials included lethargy and anorexia. Use with caution in cats with a history of neurologic disorders. Revolution Plus contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions, such as tremors, ataxia, and seizures in cats with or without a history of neurologic disorders. In humans, Revolution Plus may be irritating to skin and eyes. See full Prescribing Information at RevolutionPlusPI.com.

References

*Revolution Plus is veterinarians’ #1 trusted choice in feline parasite protection, built upon the proven 25-year legacy protection of Revolution (selamectin).

1. ZMR: Feline Most Prescribed Preventative Data 2023.

2. Revolution Plus (selamectin and sarolaner topical solution). Package insert. Zoetis Inc; 2024.

3. Zoetis Data on File, Study Report A181C-US-15-166, 2017.

Product sourced directly from the manufacturer or their approved distributor. Guaranteed genuine product backed by the manufacturer.

For

Cats

Ingredients

Active ingredient(s):

Selamectin, Sarolaner

Inactive ingredients:

Dipropylene Glycol Monomethylether, Isopropyl Alcohol, Butylated Hydroxytoluene.

Product class

Combination parasiticide, Topical

Product strength & size

Body Weight	Tube Cap Color	Tube Volume	Selamectin (per tube)	Sarolaner (per tube)
2.8 to 5.5 lbs	Gold	0.25 mL	15 mg	2.5 mg
5.6 to 11 lbs	Orange	0.5 mL	30 mg	5 mg
11.1 to 22 lbs	Green	1 mL	60 mg	10 mg
Over 22 lbs	Use the appropriate combination of tubes to cover the cat’s full body weight.

Please ensure the selected product and quantity are appropriate for your pet, as recommended by your veterinarian. For current availability, please refer to the product selection above.

Usage

Revolution Plus Topical Solution should be administered as directed by your veterinarian. Wash your hands after administration. If the product comes into contact with your skin, wash the area immediately with soap and water. Please consult your veterinarian before making any changes or discontinuing the prescribed dosing schedule.

If a dose is missed: apply Revolution Plus immediately to resume monthly dosing and notify your veterinarian. Do not apply two doses at once.

If multiple doses have been missed, consult your veterinarian prior to restarting the monthly dosing schedule. If you have questions about your pet’s prescribed dosing schedule (e.g., timing, interval), please contact your veterinarian.

Manufacturer Directions for Use*

The tube should be removed from the protective package immediately before application. Apply in just 3 simple steps. Requires no gloves.

1. Press cap until you hear a “click”.

2. Part neck hair and squeeze tube.

3. Glide tube, lift and discard. Avoid contact between the product and fingers.

Do not massage Revolution Plus into the skin. Do not apply when the haircoat is wet. Do not apply to broken skin—Revolution Plus contains alcohol. Discard empty tubes in your ordinary household refuse.

*Additional information may be provided within the manufacturer’s full Prescribing Information. Always follow the specific instructions provided by your veterinarian regarding your pet's care.

Storage

Store in a cool, dry place at a controlled temperature below 86°F. Keep this and all other medications in a secure location out of the reach of children and animals. Tubes should remain sealed in their original packaging and should only be opened at the time of dosing.

Exposure to extreme temperatures, light, or moisture can affect the integrity and effectiveness of medications. Always store this medication properly (e.g., away from the bathroom, kitchen sink, or other damp places).

Side effects

For additional information and guidance regarding the potential side effects of this product, please refer to the manufacturer’s full Prescribing Information or consult your veterinarian.

Stiff hair, clumping of hair, hair discoloration, or a slight powdery residue may be observed at the treatment site in some cats. These effects are temporary and do not affect the safety or effectiveness of the product.

The most commonly reported side effects of this medication in clinical trials were temporary loss of appetite and drowsiness.

Contact your veterinarian immediately if your pet has a seizure or experiences tremors, extreme tiredness or weakness, hypersalivation (excessive drooling), or decreased coordination (e.g., stumbling).

The information provided above may not encompass all possible side effects. Please notify your veterinarian if your pet experiences any side effects, including those listed above, or if you notice anything unusual.

Precautions

Before using this product, please review the manufacturer’s full Prescribing Information for any relevant warnings and safety precautions.

For topical use on cats only.

Not for human use. Keep this and all medications out of reach of children and animals.

Do not come into contact with or allow children to contact the application site until 4 hours post application.

In humans, Revolution Plus may be irritating to skin and eyes. Reactions such as hives, itching and skin redness have been reported in humans after accidental dermal contact with selamectin topical solution. Individuals with known hypersensitivity to selamectin topical solution should use caution or consult a health care professional before applying this product on a cat.

If contact with eyes occurs, flush eyes copiously with water; if wearing contact lenses, rinse the eyes first then remove contact lenses and continue to rinse for 5 – 10 minutes and seek medical attention. In case of ingestion by a human, contact a physician immediately.

Flammable - Keep away from heat, sparks, open flames or other sources of ignition.

Do not administer this medication to animals with a known or suspected allergy/hypersensitivity to it or any of its ingredients. Allergic reactions to medications may occur. Please inform Vetsource and your veterinarian if your pet has any known sensitivities or allergies, especially to medications and supplements.

If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways; difficulty breathing; agitation; profuse salivation; and widespread hives or itching.

Drug and food interactions

While there are no documented food or drug interactions reported for this product, potential interactions may still be possible. As with all medications, please consult your veterinarian if you have any questions or concerns prior to use. Contact your veterinarian if your pet experiences any unusual reactions when multiple medications and/or supplements are given together.

Please ensure your veterinarian is aware of all medications, supplements, and over-the-counter (OTC) products that your pet is currently using. Your veterinarian may prescribe multiple medications, even if a potential drug interaction may occur. In these instances, your veterinarian may adjust the dosages or monitor your pet more closely.

Adverse reactions

If you are concerned that your pet has experienced an adverse reaction to this medication, please contact Zoetis at 1-888-963-8471 or Vetsource Pet Owner Care at 877-738-4443.

Overdose

If you have any reason to suspect accidental consumption or overdose, call your doctor/veterinarian or the appropriate poison control resource immediately.

For humans:

The national toll-free Poison Help line, 1-800-222-1222, will connect you to your local poison center in case of emergency. This service is available nationwide and in most U.S. territories.

For animals:

The ASPCA Animal Poison Control Center is available 24 hours a day, 365 days a year at 888-426-4435.

Pet Poison Helpline also provides a 24/7 animal poison control service at 855-764-7661.

*Please note: The contact information provided above is for third-party services in the event of a potential poison-related emergency. Consultation fees may apply for these services.

Disclaimer

The content provided on this page is NOT medical advice.

All content, including the images and product description above, is intended for general informational purposes only and should not be considered a substitute for professional veterinary consultation, diagnosis, or treatment.

For additional information about this product and how it fits into your pet's individual treatment plan, please consult your veterinarian.

Last revised: 6/12/2026

$27.99 - $341.98