Prescription required

NexGard PLUS (afoxolaner, moxidectin, and pyrantel chewable tablets) Flea and Tick Protection plus Heartworm Disease Preventive for Dogs Soft Beef Flavored Chewables

Convenient one-and-done monthly dosing for parasite protection for dogs
Provides flea and tick protection for dogs
Kills adult fleas and 6 species of ticks
Effective prevention of heartworm disease
Treats and controls 3 species of hookworms and 2 species of roundworms
Tasty, beef-flavored soft chew that’s designed to be a delight for your dog
Safe for puppies as young as 8 weeks of age, weighing 4 pounds or more

NexGard PLUS (afoxolaner, moxidectin, and pyrantel chewable tablets) chews deliver next-level protection all in one tasty soft chew. One monthly chew prevents heartworm disease, protects against fleas and 6 species of ticks (black-legged tick, brown dog tick, American dog tick, lone star tick, longhorned tick, and Gulf Coast tick) and treats and controls roundworms and hookworms—plus, prevents Lyme infections as a direct result of killing black-legged ticks. NexGard PLUS chewables kill adult ﬂeas fast, before they can lay eggs, for a full month. It is also approved for prevention of Lyme infections in dogs as direct result of killing black-legged ticks. NexGard PLUS chews are safe and approved for puppies as young as 8 weeks old, weighing 4 pounds or more. Use with caution in dogs with a history of seizures or neurological disorders. Ask your veterinarian about heartworm disease prevention for dogs with monthly NexGard PLUS chewables.

IMPORTANT SAFETY INFORMATION:

NexGard PLUS (afoxolaner, moxidectin, and pyrantel chewable tablets) is safe for puppies at 8 weeks, weighing 4 pounds or more. The most frequently reported adverse reactions include diarrhea, vomiting, lethargy, and itching. Use with caution in dogs with a history of seizures or neurologic disorders. Dogs should be tested for existing heartworm infection prior to starting a preventive. For more information, click here for full prescribing information.

Product sourced directly from the manufacturer or their approved distributor. Guaranteed genuine product backed by the manufacturer.

For

Dogs

Product class

Combination parasiticide, Chewable tablet

Ingredients

Active ingredient(s): Afoxolaner, Moxidectin, Pyrantel

Product flavoring

NexGard PLUS chewable tablets are beef flavored.*

*Contains soy; according to the manufacturer, NexGard PLUS chews are gluten-free and do not contain actual beef.

Product strength & size

Weight Range	Afoxolaner (per chewable)	Moxidectin (per chewable)	Pyrantel (per chewable)
4 – 8 lbs.	9.375 mg	45 mcg	18.75 mg
8.1 – 17 lbs.	18.75 mg	90 mcg	37.5 mg
17.1 – 33 lbs.	37.5 mg	180 mcg	75 mg
33.1 – 66 lbs.	75 mg	360 mcg	150 mg
66.1 – 132 lbs.	150 mg	720 mcg	300 mg
Over 132 lbs.	Administer the appropriate combination of chewables to cover the dog’s full body weight.

Please ensure the selected product and quantity are appropriate for your pet, as recommended by your veterinarian. For current availability, please refer to the product selection above.

Usage

NexGard PLUS should be administered as directed by your veterinarian. Please consult your veterinarian before making any changes or discontinuing the prescribed dosing schedule. If you have questions about your pet’s prescribed dosing schedule (e.g., timing, interval), please contact your veterinarian.

Manufacturer Dosage and Administration*

NexGard PLUS chews can be administered with or without food. Care should be taken to ensure that the dog consumes the complete dose, and that part of the dose is not lost or refused. If a dose is missed, administer a NexGard PLUS chew and resume a monthly dosing schedule.

*Additional information may be provided within the manufacturer’s full Prescribing Information. Always follow the specific instructions provided by your veterinarian regarding your pet's care.

Storage

Store in a cool, dry place at a controlled temperature at or below 77°F with excursions permitted up to 104°F. Keep this and all other medications in a secure location out of the reach of children and animals. Tablets should remain sealed in their original packaging and should only be taken out at the time of dosing.

Exposure to extreme temperatures, light, or moisture can affect the integrity and effectiveness of medications. Always store this medication properly (e.g., away from the bathroom, kitchen sink, or other damp places), as outlined on the product label.

Side effects

The most frequently reported adverse reactions reported in clinical trials were diarrhea, vomiting, lethargy, and itching.

Contact your veterinarian immediately if your pet experiences tremors, difficulty walking, decreased coordination, or seizures.

The information provided above may not encompass all possible side effects. Please notify your veterinarian if your pet experiences any side effects, including those listed above, or if you notice anything unusual.

Precautions

Before using this product, please review the manufacturer’s full Prescribing Information for any relevant warnings and safety precautions.

For oral use in dogs only.

Not for use in humans. Keep this and all other medications out of reach of children and animals. In case of accidental ingestion, contact a physician for treatment advice.

Afoxolaner, one of the ingredients in NexGard PLUS chews, is a member of the isoxazoline class. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurologic disorders.

Treatment with fewer than six monthly doses after the last exposure to mosquitoes has not been fully evaluated and may not provide complete heartworm prevention. Prior to administration of NexGard PLUS chews, dogs should be tested for existing heartworm infection. At the discretion of the veterinarian, infected dogs should be treated with an adulticide to remove adult heartworms. NexGard PLUS chews are not effective against adult D. immitis.

The safe use of NexGard PLUS (afoxolaner, moxidectin, and pyrantel chewable tablets) chews in breeding, pregnant, or lactating dogs has not been evaluated. Discuss the risks of using this medication with your veterinarian prior to use if your pet falls into one of these categories.

Do not administer this medication to animals with a known or suspected allergy/hypersensitivity to it or any of its ingredients. Allergic reactions to medications may occur. Please inform Vetsource and your veterinarian if your pet has any known sensitivities or allergies, especially to medications and supplements.

If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways; difficulty breathing; agitation; profuse salivation; and widespread hives or itching.

Food and drug interactions

While there are no specific food or drug interactions reported for this product, potential interactions may still be possible. Please consult your veterinarian if you have any questions or concerns prior to use. Contact your veterinarian if your pet experiences any unusual reactions when multiple medications and/or supplements are given together.

Please ensure your veterinarian is aware of all medications, supplements, and over-the-counter (OTC) products that your pet is currently using. Your veterinarian may prescribe multiple medications, even if a potential drug interaction may occur. In these instances, your veterinarian may adjust the dosages or monitor your pet more closely.

Adverse reactions

If you are concerned that your pet has experienced an adverse reaction to this medication, please contact Boehringer Ingelheim Animal Health at 1-888-637-4251 or Vetsource Pet Owner Care at 877-738-4443.

Overdose

If you have any reason to suspect accidental ingestion or overdose, call your doctor/veterinarian or the appropriate poison control resource immediately.

For humans:

The national toll-free Poison Help line, 1-800-222-1222, will connect you to your local poison center in case of emergency. This service is available nationwide and in most U.S. territories.

For animals:

The ASPCA Animal Poison Control Center is available 24 hours a day, 365 days a year at 888-426-4435.

Pet Poison Helpline also provides a 24/7 animal poison control service at 855-764-7661.

*Please note: The contact information provided above is for third-party services in the event of a potential poison-related emergency. Consultation fees may apply for these services.

Disclaimer

The content provided on this page is NOT medical advice.

All content, including the images and product description above, is intended for general informational purposes only and should not be considered a substitute for professional veterinary consultation, diagnosis, or treatment.

For additional information about this product and how it fits into your pet's individual treatment plan, please consult your veterinarian.

Last revised: 7/29/2026

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Nexgard® PLUS Chews for Dogs