Boehringer Ingelheim

Heartgard® Plus Chewables

Boehringer Ingelheim

$15.99 - $163.09

Strength & Size

Dogs up to 25 lbs (Blue)

Dogs 26-50 lbs (Green)

Dogs 51-100 lbs (Brown)

Packaging

1-ct RemindMe

6 Chewables

12 Chewables

Frequency Never forget to order with AutoShip 1st order:

Quantity

Prescription required

Description

HEARTGARD Plus (ivermectin/pyrantel) Real-Beef Chewables for Dogs

Heartworm Disease Preventive

#1 dog-preferred¹ heartworm disease preventive
Effectively prevents heartworm disease
Also treats and controls roundworms and hookworms
From the brand trusted over 2 billion times⁴
Delicious once a month real-beef chew that dogs love⁵
Safe for puppies 6 weeks and older

HEARTGARD Plus (ivermectin/pyrantel) Chewables for Dogs is the #1 dog-preferred¹ preventive medication against heartworm disease – an invisible threat that can be caused by just one bite from an infected mosquito and can lead to permanent damage to a dog’s lungs and even heart.² HEARTGARD Plus chews also treat and control 3 species of hookworms and 2 species of roundworms in dogs, which are among the most prevalent intestinal nematode parasites.³ With cases in all 50 states, it’s important to protect your dog with a monthly heartworm disease preventive year-round.³ Following the use of HEARTGARD Plus chewable, digestive and neurologic side effects have been reported.

HEARTGARD Plus chews are the #1 dog-preferred chew, making the tasty, Real-Beef chew easy to give to your dog for heartworm disease prevention. HEARTGARD Plus is safe to use in dogs aged 6 weeks and older. Ask your veterinarian about preventing heartworm disease in your dog with HEARTGARD Plus chews, and make sure they have a current annual heartworm test result on file.

IMPORTANT SAFETY INFORMATION:

Following the use of HEARTGARD Plus (ivermectin/pyrantel) in dogs, digestive and neurologic side effects and itching have been reported. Safe for puppies 6 weeks of age or older with no weight restrictions. All dogs should be tested for heartworm infection before starting a preventive program. For more information, click here for full prescribing information.

References:

1. Lynn RC, Duquette RA. Chapter 6. Antiparasitic Drugs. In: Bowman DD, ed. Georgis’ Parasitology for Veterinarians. 11th ed. St. Louis, MO: Elsevier; 2021: 286-348.

2. HEARTGARD Plus (ivermectin/pyrantel) Chewables [Freedom of Information Summary; NADA140-971]. Duluth, GA: Boehringer Ingelheim Animal Health USA Inc.

3. Current Canine Guidelines for the Prevention, Diagnosis, and Management of Heartworm Infections in Dogs 2024. American Heartworm Society. https://www.heartwormsociety.org/images/pdf/2018-AHS-Canine-Guidelines.pdf. Accessed May 10, 2022.

4. Data on file at Boehringer Ingelheim

5. Data on file at Boehringer Ingelheim

6. Carithers D, Miro G. Pet Owner Educational Atlas: Parasites. Zaragosa, Spain: Grupo Asis; 2012.

7. Heartworm Basics. American Heartworm Society. https://www.heartwormsociety.org/petowner-resources/heartworm-basics. Accessed February 11, 2025.

8. Weigh the Costs Infographic. American Heartworm Society. https://d3ft8sckhnqim2.cloudfront.net/images/infographics/0010-weigh-the-costs.jpg. Accessed February 11, 2025.

Product sourced directly from the manufacturer or their approved distributor. Guaranteed genuine product backed by the manufacturer.

For

Dogs

Product class

Combination parasiticide, Chewable tablet

Ingredients

Active ingredient(s): Ivermectin, Pyrantel

Product flavoring

HEARTGARD Plus chewables are beef flavored.*

*Contains real beef; may also contain ingredients derived from corn and soy.

Product strength & size

Dog Weight	Ivermectin Content (per chewable)	Pyrantel Content (per chewable)	Color Coding on Foil Backing and Carton
0 to 25 lbs.	68 mcg	57 mg	Blue
26 to 50 lbs.	136 mcg	114 mg	Green
51 to 100 lbs.	272 mcg	227 mg	Brown
Over 100 lbs.	Administer the appropriate combination of chewables to cover the dog’s full body weight.

Please ensure the selected product and quantity are appropriate for your pet, as recommended by your veterinarian. For current availability, please refer to the product selection above.

Usage

HEARTGARD Plus should be administered as directed by your veterinarian. Please consult your veterinarian before making any changes or discontinuing the prescribed dosing schedule. If you have questions about your pet’s prescribed dosing schedule (e.g., timing, interval), please contact your veterinarian.

If a dose is missed, give HEARTGARD Plus immediately to resume monthly dosing and notify your veterinarian. Do not give more medication than prescribed or two doses at once. If multiple doses have been missed, consult your veterinarian prior to restarting the monthly dosing schedule.

Manufacturer Dosage and Administration*

Remove only one chewable at a time from the foil-backed blister card. Return the card with the remaining chewables to its box to protect the product from light.

Because most dogs find HEARTGARD Plus (ivermectin/pyrantel) palatable, the product can be offered to the dog by hand. Alternatively, it may be added intact to a small amount of dog food. The chewable should be administered in a manner that encourages the dog to chew, rather than to swallow without chewing. Chewables may be broken into pieces and fed to dogs that normally swallow treats whole. Care should be taken that the dog consumes the complete dose and treated animals should be observed for a few minutes after administration to ensure that part of the dose is not lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended.

*Additional information may be provided within the manufacturer’s full Prescribing Information. Always follow the specific instructions provided by your veterinarian regarding your pet's care.

Storage

Store in a cool, dry place at a controlled room temperature between 68°F - 77°F. Excursions between 59°F - 86°F are permitted. Protect product from light. Tablets should remain sealed in their original packaging and should only be taken out at the time of dosing.

Keep this and all other medications in a secure location out of the reach of children and animals. Exposure to extreme temperatures, light, or moisture can affect the integrity and effectiveness of medications. Always store this medication properly, as outlined on the product label.

Side effects

In clinical field trials with HEARTGARD Plus (ivermectin/pyrantel) chews, vomiting or diarrhea within 24 hours of dosing was rarely observed (1.1% of administered doses). The following adverse reactions have been reported following the use of HEARTGARD Plus chews: Depression/lethargy, vomiting, anorexia, diarrhea, mydriasis, ataxia, staggering, convulsions and hypersalivation.

Contact your veterinarian immediately if your pet experiences excessive drooling, tremors, weakness, difficulty walking, decreased coordination, or seizures.

The information provided above may not encompass all possible side effects. Please notify your veterinarian if your pet experiences any side effects, including those listed above, or if you notice anything unusual.

Precautions

Before using this product, please review the manufacturer’s full Prescribing Information for any relevant warnings and safety precautions.

For oral use in dogs only.

Keep this and all other medications out of reach of children and animals. In case of ingestion by humans, contact a physician immediately.

HEARTGARD Plus (ivermectin/pyrantel) Chewables are well tolerated. All dogs should be tested for heartworm infection before starting a preventive program. Following the use of HEARTGARD Plus chews, digestive and neurologic side effects have been reported. For more information, contact your veterinarian or refer to the full prescribing information.

Do not administer this medication to animals with a known or suspected allergy/hypersensitivity to it or any of its ingredients. Allergic reactions to medications may occur. Please inform Vetsource and your veterinarian if your pet has any known sensitivities or allergies, especially to medications and supplements.

If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways; difficulty breathing; agitation; profuse salivation; and widespread hives or itching.

Food and drug interactions

While there are no specific food or drug interactions reported for this product, potential interactions may still be possible. Please consult your veterinarian if you have any questions or concerns prior to use. Contact your veterinarian if your pet experiences any unusual reactions when multiple medications and/or supplements are given together.

Please ensure your veterinarian is aware of all medications, supplements, and over-the-counter (OTC) products that your pet is currently using. Your veterinarian may prescribe multiple medications, even if a potential drug interaction may occur. In these instances, your veterinarian may adjust the dosages or monitor your pet more closely.

Adverse reactions

If you are concerned that your pet has experienced an adverse reaction to this medication, please contact Boehringer Ingelheim Animal Health at 1-888-637-4251 or Vetsource Pet Owner Care at 877-738-4443.

Overdose

If you have any reason to suspect accidental ingestion or overdose, call your doctor/veterinarian or the appropriate poison control resource immediately.

For humans:

The national toll-free Poison Help line, 1-800-222-1222, will connect you to your local poison center in case of emergency. This service is available nationwide and in most U.S. territories.

For animals:

The ASPCA Animal Poison Control Center is available 24 hours a day, 365 days a year at 888-426-4435.

Pet Poison Helpline also provides a 24/7 animal poison control service at 855-764-7661.

*Please note: The contact information provided above is for third-party services in the event of a potential poison-related emergency. Consultation fees may apply for these services.

Disclaimer

The content provided on this page is NOT medical advice.

All content, including the images and product description above, is intended for general informational purposes only and should not be considered a substitute for professional veterinary consultation, diagnosis, or treatment.

For additional information about this product and how it fits into your pet's individual treatment plan, please consult your veterinarian.

Last revised: 7/30/2026

$15.99 - $163.09