FirstShield Trio for Dogs
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Convenient, easy-to-apply topical treatment
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Remains effective after bathing and swimming
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Kills fleas that may cause flea allergy dermatitis
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Repels and kills ticks that may transmit Lyme disease, Rocky Mountain spotted fever, babesiosis, ehrlichiosis, hepatozoonosis and anaplasmosis.
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Prevents development of adult and immature flea life stages for 30 days
FirstShield Trio for Dogs and Puppies:
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Provides 6 way protection — repels and kills fleas, ticks, mosquitoes, lice, biting & sand flies and mites (excluding mange mites).
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Kills 4 species of ticks (Rhipicephalus spp, Dermacentor variabilis, Ixodes spp, Amblyomma spp), 3 types of mosquitoes (Culex spp, Ochlerotatus spp, Aedes spp), and all stages of fleas for one month on dogs
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Repels and kills ticks that may transmit Lyme disease, Rocky Mountain Spotted fever, babesiosis, ehrlichiosis, bartonellosis, hepatozoonosis and anaplasmosis
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Easy, spot-on topical application
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Remains effective after bathing and swimming 24 hours after application
Using the applicator tip, FirstShield Trio is specially designed to spread over the dog’s body providing effective control of fleas, ticks and mosquitoes for 30 days.
FirstShield Trio for Dogs includes 4 doses per pack and is available in 5 sizes:
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Extra Small (5-10 lbs.)
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Small (11-20 lbs.)
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Medium (21-55 lbs.)
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Large (56-95 lbs.)
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Extra Large (Over 95 lbs.)
READ THE ENTIRE LABEL BEFORE EACH USE.
USE ONLY ON DOGS AND PUPPIES OVER 8 WEEKS OLD AND WEIGHING AT LEAST 5 LBS.
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DO NOT USE ON CATS — MAY BE FATAL
Due to their unique physiology and inability to metabolize certain compounds this product must not be used on cats. Keep cats away from treated dogs for 24 hours. If applied to a cat, or ingested by a cat that actively grooms a recently treated dog, contact your veterinarian immediately.
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Product sourced directly from the manufacturer or their approved distributor. Guaranteed genuine product backed by the manufacturer.
For
Dogs
Product class
Combination parasiticide, Topical solution
Ingredients
Active ingredient(s):
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Dinotefuran
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4.95%
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Pyriproxyfen
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0.44%
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Permethrin
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36.08%
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Inactive ingredients:
Complete inactive ingredients list not provided by manufacturer.
Usage
FirstShield Trio for Dogs should be applied topically as directed by your veterinarian. If you have questions about your pet’s prescribed dosing schedule (e.g., timing, interval), please contact your veterinarian.
Manufacturer Directions for Use*
It is a violation of Federal law to use this product in a manner inconsistent with its labeling.
Restrictions:
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Do not use on cats or other animals.
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Do not allow children to apply product.
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Do not have contact or allow children to have contact with treated areas until treatment is completely dry.
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Do not apply more than one tube per treatment for one dog regardless of the dog's weight.
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Do not treat your dog with more than one pesticide product at a time. Overdosing your dog can result in serious illness and even death.
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Do not apply more than once per month.
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Do not bathe or allow your dog to swim within 24 hours of application.
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Do not get the product in the dog's eyes or mouth.
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Do not allow your dog to ingest this product.
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Do not use on dogs and puppies less than 8 weeks of age and under 5 lbs.
How to Apply:
1. Ensure your dog is dry before applying the product, and ensure your dog remains dry for 24 hours after application. The dog should be standing while the product is applied. Application of product on dogs must only be done indoors.
2. Remove applicator tube from package.
3. Holding the applicator tube upright, pointing away from you and your dog’s face, place your thumb and index finger around the applicator tip under the large disk. With the other hand, grasp the stem of the applicator tip above the smaller disk. Press down firmly on the small disk until both disks meet, piercing the seal.
4. Using the applicator tip, part the hair at the base of the tail, and begin applying the product onto the skin in a continuous line from the base of the tail along the center of the back all the way up to the shoulder blades, as shown in the package insert, squeezing the applicator tube until it’s empty. Avoid superficial application to the dog’s hair.
5. Discard the empty applicator tube as outlined in the Storage and Disposal section of the package insert.
6. Repeat every month.
7. For continuous control and prevention of adult and immature flea stages, ticks, mosquitoes, lice, mites (excluding mange mites), biting flies, and sand flies, apply product monthly year-round.
*For complete product information, please refer to the manufacturer product label and package insert. Always follow the specific instructions provided by your veterinarian regarding your pet's care.
Storage
Please refer to the product label and package insert for complete information regarding the proper storage and disposal of this product.
Store in a cool, dry place at a controlled room temperature, or as otherwise indicated on the product label. Protect from freezing. Keep in a secure location out of the reach of children and animals. Individual applicator tubes should remain sealed in their original packaging and should only be taken out at the time of dosing.
Exposure to extreme temperatures, light, or moisture can affect the integrity and effectiveness of medications, supplements, and other products. Always store and dispose of this product properly, as outlined on the product label.
Side effects
Monitor your dog after application. Individual sensitivity, such as slight transitory redness, erythema, itching (pruritus) or other signs of discomfort at the site of application, may occur after using ANY pesticide product for dogs. If signs of sensitivity occur, bathe your dog with mild soap or shampoo and rinse with large amounts of water. If signs of individual animal sensitivity occur and persist, contact your veterinarian. Gastrointestinal signs such as vomiting or diarrhea have also been reported. If these signs occur, consult your veterinarian or call 1-800-999-0297. Have the product container or label with you when calling your veterinarian for advice.
The information provided above may not encompass all possible side effects. Please notify your veterinarian if your pet experiences any side effects, including those listed above, or if you notice anything unusual.
Precautions
Before using this product, please review the product label and package insert for any relevant warnings, safety precautions, and first aid information. Read the entire label before each use.
HAZARDS TO HUMANS:
WARNING: Causes substantial but temporary eye injury. Harmful if swallowed or absorbed through skin. Do not get in eyes or on clothing. Avoid contact with skin. Remove and wash contaminated clothing before reuse. Wash thoroughly with soap and water after handling and before eating, drinking, chewing gum, using tobacco products, or using the toilet.
HAZARDS TO DOMESTIC ANIMALS:
For external use on dogs only. Certain medications can interact with pesticides. Do not use this product on debilitated, aged, medicated, pregnant or nursing dogs or dogs with known organ dysfunction without first consulting a veterinarian. If your dog is exhibiting signs of and/or is being treated for skin dermatitis, talk to your veterinarian before applying any topical flea and tick control. This product is not a substitute for a prescribed heartworm preventive. Consult a veterinarian for treatment advice.
While there are no specific food or drug interactions reported for this product, potential interactions may still be possible. Consult your veterinarian if you have any questions or concerns prior to use. Please ensure your veterinarian is aware of all medications, supplements, and over-the-counter (OTC) products that your pet is currently using. Contact your veterinarian if your pet experiences any unusual reactions when multiple medications and/or supplements are given together.
Do not use this product on animals with a known or suspected allergy/hypersensitivity to it or any of its ingredients. Allergic reactions to medications, supplements, and OTC products may occur. Please inform Vetsource and your veterinarian if your pet has any known sensitivities or allergies, especially to medications and supplements.
If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways; difficulty breathing; agitation; profuse salivation; and widespread hives or itching.
Adverse reactions
If you are concerned that your pet has experienced an adverse reaction to this product, please contact Ceva Animal Health at 1-800-999-0297 or Vetsource Pet Owner Care at 877-738-4443.
Overdose
If you have any reason to suspect accidental ingestion or overdose, call your doctor/veterinarian or the appropriate poison control resource immediately.
For humans:
The national toll-free Poison Help line, 1-800-222-1222, will connect you to your local poison center in case of emergency. This service is available nationwide and in most U.S. territories.
For animals:
The ASPCA Animal Poison Control Center is available 24 hours a day, 365 days a year at 888-426-4435.
Pet Poison Helpline also provides a 24/7 animal poison control service at 855-764-7661.
*Please note: The contact information provided above is for third-party services in the event of a potential poison-related emergency. Consultation fees may apply for these services.
Disclaimer
The content provided on this page is NOT medical advice.
All content, including the images and product description above, is intended for general informational purposes only and should not be considered a substitute for professional veterinary consultation, diagnosis, or treatment.
For additional information about this product and how it fits into your pet's individual treatment plan, please consult your veterinarian.
Last revised: 9/14/2026